Stress-protective signalling of prion protein is corrupted by scrapie prions

Studies in transgenic mice revealed that neurodegeneration induced by scrapie prion (PrP(Sc)) propagation is dependent on neuronal expression of the cellular prion protein PrP(C). On the other hand, there is evidence that PrP(C) itself has a stress-protective activity. Here, we show that the toxic a...

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Main Authors: Rambold, Angelika S, Müller, Veronika, Ron, Uri, Ben-Tal, Nir, Winklhofer, Konstanze F, Tatzelt, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2486277/
https://ncbi.nlm.nih.gov/pubmed/18566584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.122
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