Off-target effects of siRNA specific for GFP

BACKGROUND: Gene knock down by RNAi is a highly effective approach to silence gene expression in experimental as well as therapeutic settings. However, this widely used methodology entails serious pitfalls, especially concerning specificity of the RNAi molecules. RESULTS: We tested the most widely u...

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Detalhes bibliográficos
Main Authors: Tschuch, Cordula, Schulz, Angela, Pscherer, Armin, Werft, Wiebke, Benner, Axel, Hotz-Wagenblatt, Agnes, Barrionuevo, Leticia Serra, Lichter, Peter, Mertens, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2443166/
https://ncbi.nlm.nih.gov/pubmed/18577207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-9-60
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