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Comparison of siRNA-induced off-target RNA and protein effects

The downregulation of many mRNAs has been observed through bioinformatic analysis of microarray results following transfection of short interfering RNAs (siRNAs). Many of these mRNA changes are due to the interaction of the siRNA guide strand with partially complementary sites and thus are considere...

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Detalhes bibliográficos
Main Authors: Alemán, Lourdes M., Doench, John, Sharp, Phillip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800510/
https://ncbi.nlm.nih.gov/pubmed/17237357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.352507
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