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Comparison of siRNA-induced off-target RNA and protein effects

The downregulation of many mRNAs has been observed through bioinformatic analysis of microarray results following transfection of short interfering RNAs (siRNAs). Many of these mRNA changes are due to the interaction of the siRNA guide strand with partially complementary sites and thus are considere...

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書目詳細資料
Main Authors: Alemán, Lourdes M., Doench, John, Sharp, Phillip A.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1800510/
https://ncbi.nlm.nih.gov/pubmed/17237357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.352507
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