Modified siRNA Structure With a Single Nucleotide Bulge Overcomes Conventional siRNA-mediated Off-target Silencing

Off-target gene silencing is a major concern when using RNA interference. Imperfect pairing of the antisense strand with unintended mRNA targets is one of the main causes of small interfering RNA (siRNA) off-target silencing. To overcome this, we have developed “bulge-siRNA,” a modified siRNA backbo...

Full description

Saved in:
Bibliographic Details
Main Authors: Dua, Pooja, Yoo, Jae Wook, Kim, Soyoun, Lee, Dong-ki
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
Subjects:
Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182346/
https://ncbi.nlm.nih.gov/pubmed/21673662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.109
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items