The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair

We have examined the interaction parameters, conformation, and functional significance of the human MutSα(·) proliferating cell nuclear antigen (PCNA) complex in mismatch repair. The two proteins associate with a 1:1 stoichiometry and a K(D) of 0.7 μm in the absence or presence of heteroduplex DNA....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Iyer, Ravi R., Pohlhaus, Timothy J., Chen, Sihong, Hura, Gregory L., Dzantiev, Leonid, Beese, Lorena S., Modrich, Paul
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2008
Gaiak:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423938/
https://ncbi.nlm.nih.gov/pubmed/18326858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800606200
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