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The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair

We have examined the interaction parameters, conformation, and functional significance of the human MutSα(·) proliferating cell nuclear antigen (PCNA) complex in mismatch repair. The two proteins associate with a 1:1 stoichiometry and a K(D) of 0.7 μm in the absence or presence of heteroduplex DNA....

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Autores principales: Iyer, Ravi R., Pohlhaus, Timothy J., Chen, Sihong, Hura, Gregory L., Dzantiev, Leonid, Beese, Lorena S., Modrich, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423938/
https://ncbi.nlm.nih.gov/pubmed/18326858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800606200
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