The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair

We have examined the interaction parameters, conformation, and functional significance of the human MutSα(·) proliferating cell nuclear antigen (PCNA) complex in mismatch repair. The two proteins associate with a 1:1 stoichiometry and a K(D) of 0.7 μm in the absence or presence of heteroduplex DNA....

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Detalhes bibliográficos
Main Authors: Iyer, Ravi R., Pohlhaus, Timothy J., Chen, Sihong, Hura, Gregory L., Dzantiev, Leonid, Beese, Lorena S., Modrich, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423938/
https://ncbi.nlm.nih.gov/pubmed/18326858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800606200
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