The MutSα-Proliferating Cell Nuclear Antigen Interaction in Human DNA Mismatch Repair

We have examined the interaction parameters, conformation, and functional significance of the human MutSα(·) proliferating cell nuclear antigen (PCNA) complex in mismatch repair. The two proteins associate with a 1:1 stoichiometry and a K(D) of 0.7 μm in the absence or presence of heteroduplex DNA....

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Hlavní autoři: Iyer, Ravi R., Pohlhaus, Timothy J., Chen, Sihong, Hura, Gregory L., Dzantiev, Leonid, Beese, Lorena S., Modrich, Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2008
Témata:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423938/
https://ncbi.nlm.nih.gov/pubmed/18326858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800606200
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