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PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
MutLα (MLH1–PMS2) is a latent endonuclease that is activated in a mismatch-, MutSα-, proliferating cell nuclear antigen (PCNA)-, replication factor C (RFC)-, and ATP-dependent manner, with nuclease action directed to the heteroduplex strand that contains a preexisting break. RFC depletion experiment...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2941292/ https://ncbi.nlm.nih.gov/pubmed/20713735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1010662107 |
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