Saccharomyces cerevisiae MutLα IS A MISMATCH REPAIR ENDONUCLEASE

MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutLα (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on integrity of a PMS2 DQHA(X)(2)E(X)(4)E motif (Kadyrov et al. (2006) Cell 126, 297-308). This sequence...

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Main Authors: Kadyrov, Farid A., Holmes, Shannon F., Arana, Mercedes E., Lukianova, Olga A., O’Donnell, Mike, Kunkel, Thomas A., Modrich, Paul
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2302834/
https://ncbi.nlm.nih.gov/pubmed/17951253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707617200
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