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Saccharomyces cerevisiae MutLα IS A MISMATCH REPAIR ENDONUCLEASE
MutL homologs are crucial for mismatch repair and genetic stability, but their function is not well understood. Human MutLα (MLH1-PMS2 heterodimer) harbors a latent endonuclease that is dependent on integrity of a PMS2 DQHA(X)(2)E(X)(4)E motif (Kadyrov et al. (2006) Cell 126, 297-308). This sequence...
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| Hoofdauteurs: | , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2007
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2302834/ https://ncbi.nlm.nih.gov/pubmed/17951253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707617200 |
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