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Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion
MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1–MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this deleterious process has remained unknown. In hum...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7035508/ https://ncbi.nlm.nih.gov/pubmed/32015124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914718117 |
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