Human MutLγ, the MLH1–MLH3 heterodimer, is an endonuclease that promotes DNA expansion

MutL proteins are ubiquitous and play important roles in DNA metabolism. MutLγ (MLH1–MLH3 heterodimer) is a poorly understood member of the eukaryotic family of MutL proteins that has been implicated in triplet repeat expansion, but its action in this deleterious process has remained unknown. In hum...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Kadyrova, Lyudmila Y., Gujar, Vaibhavi, Burdett, Vickers, Modrich, Paul L., Kadyrov, Farid A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7035508/
https://ncbi.nlm.nih.gov/pubmed/32015124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914718117
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