MutLα and Proliferating Cell Nuclear Antigen Share Binding Sites on MutSβ

MutSβ (MSH2-MSH3) mediates repair of insertion-deletion heterologies but also triggers triplet repeat expansions that cause neurological diseases. Like other DNA metabolic activities, MutSβ interacts with proliferating cell nuclear antigen (PCNA) via a conserved motif (QXX(L/I)XXFF). We demonstrate...

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Detalhes bibliográficos
Main Authors: Iyer, Ravi R., Pluciennik, Anna, Genschel, Jochen, Tsai, Miaw-Sheue, Beese, Lorena S., Modrich, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857047/
https://ncbi.nlm.nih.gov/pubmed/20154325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104125
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