Inhibition of ZAP-70 Kinase Activity via an Analog-sensitive Allele Blocks T Cell Receptor and CD28 Superagonist Signaling

ZAP-70 is a cytoplasmic protein tyrosine kinase that is required for T cell antigen receptor (TCR) signaling. Both mice and humans deficient in ZAP-70 fail to develop functional T cells, thus demonstrating its necessity for T cell development and function. There is currently no highly specific, cell...

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Bibliografiske detaljer
Main Authors: Levin, Susan E., Zhang, Chao, Kadlecek, Theresa A., Shokat, Kevan M., Weiss, Arthur
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Mechanisms of Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2397475/
https://ncbi.nlm.nih.gov/pubmed/18378687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709000200
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