Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo

Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates generation of amyloid beta (Abeta), a pathological hallmark of Alzheimer’s disease. We investigated the impact of BACE1 protein level on endogenous Abeta. Endogenous Abeta and BACE1 protein levels were concurrently and significa...

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Hlavní autoři: Hirata-Fukae, Chiho, Sidahmed, Elkhansa Hassan, Gooskens, Thomas P., Aisen, Paul S., Dewachter, Ilse, Devijver, Herman, Van Leuven, Fred, Matsuoka, Yasuji
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377398/
https://ncbi.nlm.nih.gov/pubmed/18343582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2008.02.032
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