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β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice
The generation of amyloid peptides (Aβ) from the amyloid precursor protein (APP) is initiated by β-secretase (BACE), whereas subsequent γ-secretase cleavage mediated by presenilin-1, produces Aβ peptides mainly of 40 or 42 amino acids long. In addition, alternative β′-cleavage of APP at position 11...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Investigative Pathology
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1618675/ https://ncbi.nlm.nih.gov/pubmed/15509532 |
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