β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Increases Amyloid Deposition in Brain Parenchyma but Reduces Cerebrovascular Amyloid Angiopathy in Aging BACE × APP[V717I] Double-Transgenic Mice

The generation of amyloid peptides (Aβ) from the amyloid precursor protein (APP) is initiated by β-secretase (BACE), whereas subsequent γ-secretase cleavage mediated by presenilin-1, produces Aβ peptides mainly of 40 or 42 amino acids long. In addition, alternative β′-cleavage of APP at position 11...

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Hlavní autoři: Willem, Michael, Dewachter, Ilse, Smyth, Neil, Van Dooren, Tom, Borghgraef, Peter, Haass, Christian, Van Leuven, Fred
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2004
Témata:
Original Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1618675/
https://ncbi.nlm.nih.gov/pubmed/15509532
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