Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice

BACKGROUND: Inflammation is suspected to contribute to the progression and severity of neurodegeneration in Alzheimer's disease (AD). Transgenic mice overexpressing the london mutant of amyloid precursor protein, APP [V717I], robustly recapitulate the amyloid pathology of AD. METHODS: Early and...

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Detalhes bibliográficos
Main Authors: Heneka, Michael T, Sastre, Magdalena, Dumitrescu-Ozimek, Lucia, Dewachter, Ilse, Walter, Jochen, Klockgether, Thomas, Van Leuven, Fred
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1274341/
https://ncbi.nlm.nih.gov/pubmed/16212664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-2-22
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