Nonsteroidal Anti-Inflammatory Drugs and Peroxisome Proliferator-Activated Receptor-γ Agonists Modulate Immunostimulated Processing of Amyloid Precursor Protein through Regulation of β-Secretase

Long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk for Alzheimer's disease (AD). To determine the mechanisms by which inflammation affects AD and how NSAIDs protect against it, we stimulated neuroblastoma cells stably transfected with amyloid precursor prote...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Sastre, Magdalena, Dewachter, Ilse, Landreth, Gary E., Willson, Timothy M., Klockgether, Thomas, van Leuven, Fred, Heneka, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2003
Assuntos:
Cellular/Molecular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6740896/
https://ncbi.nlm.nih.gov/pubmed/14586007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-30-09796.2003
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