Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

Epidemiological evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) decrease the risk for Alzheimer's disease (AD). Certain NSAIDs can activate the peroxisome proliferator-activated receptor-γ (PPARγ), which is a nuclear transcriptional regulator. Here we show that PPARγ deplet...

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Detalhes bibliográficos
Main Authors: Sastre, Magdalena, Dewachter, Ilse, Rossner, Steffen, Bogdanovic, Nenad, Rosen, Evan, Borghgraef, Peter, Evert, Bernd O., Dumitrescu-Ozimek, Lucia, Thal, Dietmar R., Landreth, Gary, Walter, Jochen, Klockgether, Thomas, van Leuven, Fred, Heneka, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1326151/
https://ncbi.nlm.nih.gov/pubmed/16407166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0503839103
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