Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis

Presenilins (PSs) are components of the γ-secretase complex that mediates intramembranous cleavage of type I membrane proteins. We show that γ-secretase is involved in the regulation of cellular lipoprotein uptake. Loss of γ-secretase function decreased endocytosis of low-density lipoprotein (LDL) r...

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Pubblicato in:J Neurosci
Autori principali: Tamboli, Irfan Y., Prager, Kai, Thal, Dietmar R., Thelen, Karin M., Dewachter, Ilse, Pietrzik, Claus U., St. George-Hyslop, Peter, Sisodia, Sangram S., De Strooper, Bart, Heneka, Michael T., Filippov, Mikhail A., Müller, Ulrike, van Leuven, Fred, Lütjohann, Dieter, Walter, Jochen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2008
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6671640/
https://ncbi.nlm.nih.gov/pubmed/19005074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2635-08.2008
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