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Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice
The hypothesis that amyloid pathology precedes and induces the tau pathology of Alzheimer’s disease is experimentally supported here through the identification of GSK-3 isozymes as a major link in the signaling pathway from amyloid to tau pathology. This study compares two novel bigenic mouse models...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Investigative Pathology
2008
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2258274/ https://ncbi.nlm.nih.gov/pubmed/18258852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070904 |
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