Neuronal or Glial Expression of Human Apolipoprotein E4 Affects Parenchymal and Vascular Amyloid Pathology Differentially in Different Brain Regions of Double- and Triple-Transgenic Mice

Apolipoprotein E4 (ApoE4) is associated with Alzheimer’s disease by unknown mechanisms. We generated six transgenic mice strains expressing human ApoE4 in combination with mutant amyloid precursor protein (APP) and mutant presenilin-1 (PS1) in single-, double-, or triple-transgenic combinations. Dif...

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Main Authors: Van Dooren, Tom, Muyllaert, David, Borghgraef, Peter, Cresens, Annelies, Devijver, Herman, Van der Auwera, Ingrid, Wera, Stefaan, Dewachter, Ilse, Van Leuven, Fred
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592662/
https://ncbi.nlm.nih.gov/pubmed/16400027
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