Neurodegeneration and Neuroinflammation in cdk5/p25-Inducible Mice : A Model for Hippocampal Sclerosis and Neocortical Degeneration

The cyclin-dependent kinase cdk5 is atypically active in postmitotic neurons and enigmatic among the kinases proposed as molecular actors in neurodegeneration. We generated transgenic mice to express p25, the N-terminally truncated p35 activator of cdk5, in forebrain under tetracycline control (TET-...

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Detalhes bibliográficos
Main Authors: Muyllaert, David, Terwel, Dick, Kremer, Anna, Sennvik, Kristina, Borghgraef, Peter, Devijver, Herman, Dewachter, Ilse, Van Leuven, Fred
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2008
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2312368/
https://ncbi.nlm.nih.gov/pubmed/18202185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2008.070693
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