Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration

Adeno-associated virus (AAV)–mediated expression of wild-type or mutant P301L protein tau produces massive degeneration of pyramidal neurons without protein tau aggregation. We probed this novel model for genetic and structural factors and early parameters of pyramidal neurodegeneration. In yellow f...

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Détails bibliographiques
Auteurs principaux: Jaworski, Tomasz, Lechat, Benoit, Demedts, David, Gielis, Lies, Devijver, Herman, Borghgraef, Peter, Duimel, Hans, Verheyen, Fons, Kügler, Sebastian, Van Leuven, Fred
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2011
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181369/
https://ncbi.nlm.nih.gov/pubmed/21839061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.025
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