Dendritic Degeneration, Neurovascular Defects, and Inflammation Precede Neuronal Loss in a Mouse Model for Tau-Mediated Neurodegeneration

Adeno-associated virus (AAV)–mediated expression of wild-type or mutant P301L protein tau produces massive degeneration of pyramidal neurons without protein tau aggregation. We probed this novel model for genetic and structural factors and early parameters of pyramidal neurodegeneration. In yellow f...

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Detaylı Bibliyografya
Asıl Yazarlar: Jaworski, Tomasz, Lechat, Benoit, Demedts, David, Gielis, Lies, Devijver, Herman, Borghgraef, Peter, Duimel, Hans, Verheyen, Fons, Kügler, Sebastian, Van Leuven, Fred
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Investigative Pathology 2011
Konular:
Regular Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3181369/
https://ncbi.nlm.nih.gov/pubmed/21839061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.06.025
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