Palmitoylated APP Forms Dimers, Cleaved by BACE1

A major rate-limiting step for Aβ generation and deposition in Alzheimer’s disease brains is BACE1-mediated cleavage (β-cleavage) of the amyloid precursor protein (APP). We previously reported that APP undergoes palmitoylation at two cysteine residues (Cys(186) and Cys(187)) in the E1-ectodomain. 8–...

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Bibliographic Details
Published in:PLoS One
Main Authors: Bhattacharyya, Raja, Fenn, Rebecca H., Barren, Cory, Tanzi, Rudolph E., Kovacs, Dora M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119739/
https://ncbi.nlm.nih.gov/pubmed/27875558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166400
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