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Palmitoylated APP Forms Dimers, Cleaved by BACE1
A major rate-limiting step for Aβ generation and deposition in Alzheimer’s disease brains is BACE1-mediated cleavage (β-cleavage) of the amyloid precursor protein (APP). We previously reported that APP undergoes palmitoylation at two cysteine residues (Cys(186) and Cys(187)) in the E1-ectodomain. 8–...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5119739/ https://ncbi.nlm.nih.gov/pubmed/27875558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0166400 |
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