Cardiac Restricted Overexpression of Kinase-dead Mammalian Target of Rapamycin (mTOR) Mutant Impairs the mTOR-mediated Signaling and Cardiac Function

Mammalian target of rapamycin (mTOR) is a key regulator for cell growth through modulating components of the translation machinery. Previously, numerous pharmacological studies using rapamycin suggested that mTOR has an important role in regulating cardiac hypertrophic growth. To further investigate...

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Bibliographic Details
Main Authors: Shen, Wei-Hua, Chen, Zhuang, Shi, Shu, Chen, Hanying, Zhu, Wuqiang, Penner, Anne, Bu, Guixue, Li, Wei, Boyle, David W., Rubart, Michael, Field, Loren J., Abraham, Robert, Liechty, Edward A., Shou, Weinian
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2008
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376248/
https://ncbi.nlm.nih.gov/pubmed/18326485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801510200
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