Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts

Studies of Li-Fraumeni syndrome fibroblasts heterozygous for germline TP53 mutations have shown that loss of heterozygosity (LOH) occurs during passaging and is associated with genomic instability, such as chromosomal aberrations and aneuploidy. to investigate the genomic changes associated with LOH...

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Bibliographic Details
Main Authors: Burt, E C, James, L A, Greaves, M J, Birch, J M, Boyle, J M, Varley, J M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2000
Subjects:
Regular Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374657/
https://ncbi.nlm.nih.gov/pubmed/10945493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1292
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