Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts

Studies of Li-Fraumeni syndrome fibroblasts heterozygous for germline TP53 mutations have shown that loss of heterozygosity (LOH) occurs during passaging and is associated with genomic instability, such as chromosomal aberrations and aneuploidy. to investigate the genomic changes associated with LOH...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Burt, E C, James, L A, Greaves, M J, Birch, J M, Boyle, J M, Varley, J M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2000
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374657/
https://ncbi.nlm.nih.gov/pubmed/10945493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1292
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