Genomic alterations associated with loss of heterozygosity for TP53 in Li-Fraumeni syndrome fibroblasts

Studies of Li-Fraumeni syndrome fibroblasts heterozygous for germline TP53 mutations have shown that loss of heterozygosity (LOH) occurs during passaging and is associated with genomic instability, such as chromosomal aberrations and aneuploidy. to investigate the genomic changes associated with LOH...

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Main Authors: Burt, E C, James, L A, Greaves, M J, Birch, J M, Boyle, J M, Varley, J M
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2000
Ábhair:
Regular Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374657/
https://ncbi.nlm.nih.gov/pubmed/10945493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1054/bjoc.2000.1292
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