An extended Li-Fraumeni kindred with gastric carcinoma and a codon 175 mutation in TP53.

We present an extended family with Li-Fraumeni syndrome characterised by gastric and breast carcinoma, glioma, sarcoma, and leukaemia. This family showed strong evidence of linkage to TP53, and three of four tumours analysed showed loss of the wild type allele. A codon 175 missense mutation was iden...

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Autores principales: Varley, J M, McGown, G, Thorncroft, M, Tricker, K J, Teare, M D, Santibanez-Koref, M F, Martin, J, Birch, J M, Evans, D G
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1051773/
https://ncbi.nlm.nih.gov/pubmed/8825920
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