Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy

The epidermal growth factor receptor (EGFR) is a validated target in squamous cell carcinoma (SCC) of the head and neck. Most patients, however, do not respond or develop resistance to this agent. Mammalian target of rapamycin (mTOR) is involved in the pathogenesis of SCC of the head and neck (SCCHN...

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Dettagli Bibliografici
Autori principali: Jimeno, A, Kulesza, P, Wheelhouse, J, Chan, A, Zhang, X, Kincaid, E, Chen, R, Clark, D P, Forastiere, A, Hidalgo, M
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2007
Soggetti:
Translational Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360107/
https://ncbi.nlm.nih.gov/pubmed/17342092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603656
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