Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy

The epidermal growth factor receptor (EGFR) is a validated target in squamous cell carcinoma (SCC) of the head and neck. Most patients, however, do not respond or develop resistance to this agent. Mammalian target of rapamycin (mTOR) is involved in the pathogenesis of SCC of the head and neck (SCCHN...

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Detalhes bibliográficos
Main Authors: Jimeno, A, Kulesza, P, Wheelhouse, J, Chan, A, Zhang, X, Kincaid, E, Chen, R, Clark, D P, Forastiere, A, Hidalgo, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360107/
https://ncbi.nlm.nih.gov/pubmed/17342092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603656
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