Dual inhibition of EGFR and mTOR pathways in small cell lung cancer

BACKGROUND: In this report we investigated the combination of epidermal growth factor receptor (EGFR) and mammalian target of rapamycin (mTOR) pathway inhibition as a possible new therapeutic strategy for small cell lung cancer (SCLC). METHODS: EGFR, p-AKT, p-ERK, p-mTOR and p-p70s6K protein express...

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Main Authors: Schmid, K, Bago-Horvath, Z, Berger, W, Haitel, A, Cejka, D, Werzowa, J, Filipits, M, Herberger, B, Hayden, H, Sieghart, W
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2010
Teme:
Translational Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938245/
https://ncbi.nlm.nih.gov/pubmed/20683448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605761
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