Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma

BACKGROUND: We examine the potential value of a series of clinically relevant PI3K-mTOR inhibitors alone, or in combination with histone deacetylase inhibitors, in a model of head and neck squamous cell carcinoma (HNSCC). METHODS: Head and neck squamous cell carcinoma cell lines, human keratinocyte...

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Detalhes bibliográficos
Main Authors: Erlich, R B, Kherrouche, Z, Rickwood, D, Endo-Munoz, L, Cameron, S, Dahler, A, Hazar-Rethinam, M, de Long, L M, Wooley, K, Guminski, A, Saunders, N A
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251846/
https://ncbi.nlm.nih.gov/pubmed/22116303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.495
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