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PI3K/Akt/mTOR inhibitors in breast cancer

Activation of the phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is common in breast cancer. There is preclinical data to support inhibition of the pathway, and phase I to Ⅲ trials involving inhibitors of the pathway have been or are being conducted in solid tumors...

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Autori principali: Joycelyn JX Lee, Kiley Loh, Yoon-Sim Yap
Natura: Artigo
Lingua:Inglês
Pubblicazione: China Anti-Cancer Association 2015-12-01
Serie:Cancer Biology & Medicine
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Accesso online:http://www.cancerbiomed.org/index.php/cocr/article/view/888
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