The synergistic interaction of MEK and PI3K inhibitors is modulated by mTOR inhibition

BACKGROUND: Combined targeting of MAPK and PI3K signalling pathways may be necessary for optimal therapeutic activity in cancer. This study evaluated the MEK inhibitors AZD6244 and PD0325901, alone and in combination with the dual mTOR/PI3K inhibitor NVP-BEZ235 or the PI3K inhibitor GDC-0941, in thr...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Haagensen, E J, Kyle, S, Beale, G S, Maxwell, R J, Newell, D R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2012
Gaiak:
Translational Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326670/
https://ncbi.nlm.nih.gov/pubmed/22415236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.70
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