Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

BACKGROUND: The PI3K–mTOR (phosphoinositide 3-kinase–mammalian target of rapamycin kinase) pathway is activated in the majority of tumours, and there is interest in assessing whether inhibitors of PI3K or mTOR kinase have efficacy in treating cancer. Here, we define the effectiveness of specific mTO...

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Detalhes bibliográficos
Main Authors: García-Martínez, J M, Wullschleger, S, Preston, G, Guichard, S, Fleming, S, Alessi, D R, Duce, S L
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068512/
https://ncbi.nlm.nih.gov/pubmed/21407213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.83
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