Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice

BACKGROUND: The PI3K–mTOR (phosphoinositide 3-kinase–mammalian target of rapamycin kinase) pathway is activated in the majority of tumours, and there is interest in assessing whether inhibitors of PI3K or mTOR kinase have efficacy in treating cancer. Here, we define the effectiveness of specific mTO...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: García-Martínez, J M, Wullschleger, S, Preston, G, Guichard, S, Fleming, S, Alessi, D R, Duce, S L
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group 2011
विषय:
Translational Therapeutics
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3068512/
https://ncbi.nlm.nih.gov/pubmed/21407213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.83
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