Dual EGFR and mTOR targeting in squamous cell carcinoma models, and development of early markers of efficacy

The epidermal growth factor receptor (EGFR) is a validated target in squamous cell carcinoma (SCC) of the head and neck. Most patients, however, do not respond or develop resistance to this agent. Mammalian target of rapamycin (mTOR) is involved in the pathogenesis of SCC of the head and neck (SCCHN...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Jimeno, A, Kulesza, P, Wheelhouse, J, Chan, A, Zhang, X, Kincaid, E, Chen, R, Clark, D P, Forastiere, A, Hidalgo, M
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2007
Sujets:
Translational Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2360107/
https://ncbi.nlm.nih.gov/pubmed/17342092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6603656
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