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A critical developmental switch defines the kinetics of kidney cyst formation after loss of Pkd1

Autosomal dominant polycystic kidney disease is an important cause of end-stage renal disease, for which there is no proven therapy1. Mutations in PKD1 (the gene encoding polycystin-1) are the principal cause of this disease. The disease begins in utero2 and is slowly progressive, but it is not know...

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Autores principales: Piontek, Klaus, Menezes, Luis F, Garcia-Gonzalez, Miguel A, Huso, David L, Germino, Gregory G
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2302790/
https://ncbi.nlm.nih.gov/pubmed/17965720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1675
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