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Comparison of BRCT domains of BRCA1 and 53BP1: A biophysical analysis

53BP1 interacts with the DNA-binding core domain of the tumor suppressor p53 and enhances p53-mediated transcriptional activation. The p53-binding region of 53BP1 maps to the C-terminal BRCT domains, which are homologous to those found in the breast cancer protein BRCA1 and in other proteins involve...

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Detalhes bibliográficos
Main Authors: Ekblad, Caroline M.S., Friedler, Assaf, Veprintsev, Dmitry, Weinberg, Richard L., Itzhaki, Laura S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2286730/
https://ncbi.nlm.nih.gov/pubmed/14978302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.03461404
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