Llwytho...

“Similarity Trap” in protein-protein interactions could be carcinogenic: simulations of p53 core domain complexed with 53BP1 and BRCA1 BRCT domains

Similar binding sites often imply similar protein-protein interactions and similar functions; however, similar binding sites may also constitute traps for nonfunctional associations. How are similar sites distinguished to prevent misassociations? BRCT domain from breast cancer-susceptibility gene pr...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Liu, Jin, Pan, Yongping, Ma, Buyong, Nussinov, Ruth
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2006
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2429992/
https://ncbi.nlm.nih.gov/pubmed/17161371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2006.10.009
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