Glucuronidation of Monohydroxylated Warfarin Metabolites by Human Liver Microsomes and Human Recombinant UDP-Glucuronosyltransferases

Our understanding of human phase II metabolic pathways which facilitate detoxification and excretion of warfarin (Coumadin) is limited. The goal of this study was to test the hypothesis that there are specific human hepatic and extrahepatic UDP-glucuronosyltransferase (UGT) isozymes, which are respo...

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Hauptverfasser: Zielinska, Agnieszka, Lichti, Cheryl F., Bratton, Stacie, Mitchell, Neil C., Gallus-Zawada, Anna, Le, Vi-Huyen, Finel, Moshe, Miller, Grover P., Radominska-Pandya, Anna, Moran, Jeffery H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275122/
https://ncbi.nlm.nih.gov/pubmed/17921187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.129858
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