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Role of Human UDP-Glucuronosyltransferases in the Biotransformation of the Triazoloacridinone and Imidazoacridinone Antitumor Agents C-1305 and C-1311: Highly Selective Substrates for UGT1A10

5-Diethylaminoethylamino-8-hydroxyimidazoacridinone, C-1311 (NSC-645809), is an antitumor agent shown to be effective against breast cancer in phase II clinical trials. A similar compound, 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone, C-1305, shows high activity against experimental tumors...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Fedejko-Kap, Barbara, Bratton, Stacie M., Finel, Moshe, Radominska-Pandya, Anna, Mazerska, Zofia
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The American Society for Pharmacology and Experimental Therapeutics 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422538/
https://ncbi.nlm.nih.gov/pubmed/22659092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.045401
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