Metabolic Transformation of Antitumor Acridinone C-1305 but Not C-1311 via Selective Cellular Expression of UGT1A10 Increases Cytotoxic Response: Implications for Clinical Use

The acridinone derivates 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8-hydroxyimidazoacridinone (C-1311) are promising antitumor agents with high activity against several experimental cellular and tumor models and are under evaluation in preclinical a...

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Bibliographic Details
Main Authors: Pawlowska, Monika, Chu, Rong, Fedejko-Kap, Barbara, Augustin, Ewa, Mazerska, Zofia, Radominska-Pandya, Anna, Chambers, Timothy C.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3558869/
https://ncbi.nlm.nih.gov/pubmed/23160818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.047811
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