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CYP3A4 overexpression enhances the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in CHO cells
AIM: To examine how the higher expression level of CYP3A4 isoenzyme influenced the cytotoxicity of the antitumor triazoloacridinone derivative C-1305 in Chinese hamster ovary (CHO) cells. METHODS: Three CHO cell lines were examined: wild-type CHO cells; CHO-HR cells with overexpression of human cyto...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4086498/ https://ncbi.nlm.nih.gov/pubmed/23160340 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2012.132 |
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