Analysis of R- and S-Hydroxywarfarin Glucuronidation Catalyzed by Human Liver Microsomes and Recombinant UDP-Glucuronosyltransferases

Coumadin (R-, S-warfarin) is a challenging drug to accurately dose, both initially and for maintenance, because of its narrow therapeutic range and wide interpatient variability and is typically administered as a racemic (Rac) mixture, which complicates the biotransformation pathways. The goal of th...

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Hlavní autoři: Bratton, Stacie M., Mosher, Carrie M., Khallouki, Farid, Finel, Moshe, Court, Michael H., Moran, Jeffery H., Radominska-Pandya, Anna
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2012
Témata:
Metabolism, Transport, and Pharmacogenomics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251030/
https://ncbi.nlm.nih.gov/pubmed/21972237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.184721
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