Multiple UDP- Glucuronosyltransferases in Human Liver Microsomes Glucuronidate Both R- and S-7-Hydroxywarfarin into Two Metabolites

The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through direct inhibition of cytochromes P450 and thu...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Pugh, C. Preston, Pouncey, Dakota L, Hartman, Jessica H., Nshimiyimana, Robert, Desrochers, Linda P., Goodwin, Thomas E., Boysen, Gunnar, Miller, Grover P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258421/
https://ncbi.nlm.nih.gov/pubmed/25447818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.10.006
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